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Explore Cell Division times during bacterial cytokinesis

Abstract

Filamenting temperature-sensitive mutant Z (FtsZ), an essential cell division protein in bacteria, has recently emerged as an important and exploitable antibacterial target. The perturbation of FtsZ assembly is found to have effect on cell cytokinesis and cell survival. Cell division time is an important physical parameter to cell cytokinesis. \textbf{Here, the theoretical framework that has been developed by combining a phase field model for rod-shaped cells with a kinetic description for FtsZ ring maintenance, would be extended to explore cell division times during bacterial cytokinesis. Cell division times around 72 s in the numerical studies have the same magnitude of the division time of several minutes observed physiologically. The dependences of cell division times are thoroughly investigated on the parameters, such as the initial state of rod-shaped cells and various kinetic rates of FtsZ assembly dynamics. The theoretical analysis for the relations between cell division times and these parameters are found to coincide well with the numerical calculated results. }

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Publication details

The article was received on 26 Jul 2017, accepted on 07 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7CP05050J
Citation: Phys. Chem. Chem. Phys., 2017, Accepted Manuscript
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    Explore Cell Division times during bacterial cytokinesis

    Z. He and K. K. Guo, Phys. Chem. Chem. Phys., 2017, Accepted Manuscript , DOI: 10.1039/C7CP05050J

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