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Issue 39, 2017
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Study of the interaction between cisplatin and the Au18(SR)14 cluster: in search of an appropriate cisplatin carrier

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Abstract

Cisplatin is a well known anti-cancer drug and considered as essential by the World Health Organization. However, cisplatin features side effects during medical treatments due to its lack of selectivity resulting in the indiscriminate death of cells including healthy cells. To solve this issue, it is mandatory to improve its delivery towards affected organs or tissues. The well known bio-compatibility of gold clusters encouraged us to study the interaction between cisplatin molecules and the Au18(SR)14 cluster (named Au18) and our DFT calculations have provided insight into this aspect. Calculated adsorption energy values of the cisplatinn/Au18 complexes are within the 0.5–3.6 eV range, which attests to their unique interaction. In addition, their calculated optical absorption (UV-vis) and circular dichroism (CD) spectra display distinct peaks in such a manner that UV/CD spectra can be used as fingerprints by experimentalists.

Graphical abstract: Study of the interaction between cisplatin and the Au18(SR)14 cluster: in search of an appropriate cisplatin carrier

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Publication details

The article was received on 03 Jul 2017, accepted on 20 Sep 2017 and first published on 20 Sep 2017


Article type: Communication
DOI: 10.1039/C7CP04452F
Citation: Phys. Chem. Chem. Phys., 2017,19, 26545-26550
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    Study of the interaction between cisplatin and the Au18(SR)14 cluster: in search of an appropriate cisplatin carrier

    O. Palacios-Álvarez and A. Tlahuice-Flores, Phys. Chem. Chem. Phys., 2017, 19, 26545
    DOI: 10.1039/C7CP04452F

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