Jump to main content
Jump to site search

Issue 36, 2017
Previous Article Next Article

Fast flip–flop of halogenated cobalt bis(dicarbollide) anion in a lipid bilayer membrane

Author affiliations

Abstract

Transmembrane translocation (flip–flop) of cobalt bis(dicarbollide) (COSAN) anions, elicited by application of a voltage-jump across the lipid bilayer membrane, manifested itself in monoexponential electrical current transients in the microsecond time scale. Halogenation of COSAN led to multi-fold acceleration of the flip–flop, the effect increasing with the molecular weight of the halogens. The exception was a fluorinated analog which exhibited slowing of the translocation kinetics. Measurements of the fluorescence ratio of the dye di-4-ANEPPS in lipid vesicles showed significant differences in the adsorption of studied hydrophobic anions. Based on these data, it can be concluded that COSAN and COSAN-F2 were located on the surface of the lipid membrane in the cisoid conformation increasing the dipole potential of the lipid membrane, while other halogenated COSAN analogs were adsorbed in the transoid conformation. Differences in the flip–flop kinetics of COSAN analogs were attributed to variation in the molecular volume of the anions and their orientation on the membrane surface.

Graphical abstract: Fast flip–flop of halogenated cobalt bis(dicarbollide) anion in a lipid bilayer membrane

Back to tab navigation

Publication details

The article was received on 22 Jun 2017, accepted on 17 Aug 2017 and first published on 07 Sep 2017


Article type: Paper
DOI: 10.1039/C7CP04207H
Citation: Phys. Chem. Chem. Phys., 2017,19, 25122-25128
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Fast flip–flop of halogenated cobalt bis(dicarbollide) anion in a lipid bilayer membrane

    T. I. Rokitskaya, I. D. Kosenko, I. B. Sivaev, Y. N. Antonenko and V. I. Bregadze, Phys. Chem. Chem. Phys., 2017, 19, 25122
    DOI: 10.1039/C7CP04207H

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements