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Issue 29, 2017
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Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

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Abstract

The nucleation of glycine from aqueous supersaturated solution has been studied using non-photochemical laser-induced nucleation (NPLIN), ultrasound (sonocrystallization), and mechanical shock of sample vials. It was found that at higher supersaturation, samples were more susceptible to nucleation and produced more of the γ-glycine polymorph. The results are described in terms of a mechanism common to all three nucleation methods, involving the induction of cavitation events and pressure shockwaves. The switch in preference from α- to γ-glycine was observed to occur over a narrower range of supersaturation values for NPLIN. We attribute this to induction of cavitation events with higher energies, which result in higher localized pressures and supersaturations. Experiments on NPLIN using circularly versus linearly polarized light showed no evidence for binary polarization switching control of glycine polymorphism.

Graphical abstract: Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

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Publication details

The article was received on 11 May 2017, accepted on 06 Jul 2017 and first published on 13 Jul 2017


Article type: Paper
DOI: 10.1039/C7CP03146G
Citation: Phys. Chem. Chem. Phys., 2017,19, 19386-19392
  • Open access: Creative Commons BY license
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    Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

    Y. Liu, M. H. van den Berg and A. J. Alexander, Phys. Chem. Chem. Phys., 2017, 19, 19386
    DOI: 10.1039/C7CP03146G

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