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Recognition of Chiral Zwitterionic Interactions at Nanoscale Interfaces by Chiroplasmonic Nanosensors

Abstract

The ability to detect chiral molecules renders plasmonic nanosensors to be promising tools for the study of chirality phenomena in living systems. Using gold nanorods based plasmonic nanosensors, we investigated here typically chiral zwitterionic electrostatic (Zw-Es) and hydrogen-bonding (Hb) interactions occurring via amine and carboxylic group at nanoscale interfaces in aqueous solutions. Our results reveal that plasmonic Circular Dichroism (CD) responses of the nanosensors can be of both conformational sensitivity and chiral selectivity to the interfacial molecular interactions. Such a dual function of plasmonic nanosensors enables a new chiroptical way to differentiate between chiral Zw-Es and Hb interactions, to monitor the transformation between these two interaction forces, and particularly to recognize homochiral Zw-Es interactions in solutions. Together with surface enhanced Raman scattering (SERS) technique, this plasmonic CD based biosensing could have important values for an insightful understanding of chirality-dependent molecular recognitions in biological and pharmaceutical systems.

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Publication details

The article was accepted on 30 May 2017 and first published on 01 Jun 2017


Article type: Paper
DOI: 10.1039/C7CP03004E
Citation: Phys. Chem. Chem. Phys., 2017, Accepted Manuscript
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    Recognition of Chiral Zwitterionic Interactions at Nanoscale Interfaces by Chiroplasmonic Nanosensors

    W. Zhao, R. Wang, H. Wei, J. Li, Y. Ji, X. Jiang, X. Wu and X. Zhang, Phys. Chem. Chem. Phys., 2017, Accepted Manuscript , DOI: 10.1039/C7CP03004E

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