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Issue 37, 2017
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DNA protection by ectoine from ionizing radiation: molecular mechanisms

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Abstract

Ectoine, a compatible solute and osmolyte, is known to be an effective protectant of biomolecules and whole cells against heating, freezing and extreme salinity. Protection of cells (human keratinocytes) by ectoine against ultraviolet radiation has also been reported by various authors, although the underlying mechanism is not yet understood. We present the first electron irradiation of DNA in a fully aqueous environment in the presence of ectoine and at high salt concentrations. The results demonstrate effective protection of DNA by ectoine against the induction of single-strand breaks by ionizing radiation. The effect is explained by an increase in low-energy electron scattering at the enhanced free-vibrational density of states of water due to ectoine, as well as the use of ectoine as an ˙OH-radical scavenger. This was demonstrated by Raman spectroscopy and electron paramagnetic resonance (EPR).

Graphical abstract: DNA protection by ectoine from ionizing radiation: molecular mechanisms

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Publication details

The article was received on 02 May 2017, accepted on 31 Aug 2017 and first published on 31 Aug 2017


Article type: Paper
DOI: 10.1039/C7CP02860A
Citation: Phys. Chem. Chem. Phys., 2017,19, 25717-25722
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    DNA protection by ectoine from ionizing radiation: molecular mechanisms

    M. B. Hahn, S. Meyer, M. Schröter, H. Kunte, T. Solomun and H. Sturm, Phys. Chem. Chem. Phys., 2017, 19, 25717
    DOI: 10.1039/C7CP02860A

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