Jump to main content
Jump to site search

Issue 30, 2017
Previous Article Next Article

Ultrafast dynamics in the DNA building blocks thymidine and thymine initiated by ionizing radiation

Author affiliations

Abstract

Understanding how energetic charged particles damage DNA is crucial for improving radiotherapy techniques such as hadron therapy and for the development of new radiosensitizer drugs. In the present study, the damage caused by energetic particles was simulated by measuring the action of extreme ultraviolet (XUV) attosecond pulses on the DNA building blocks thymine and thymidine. This allowed the ultrafast processes triggered by direct ionization to be probed with an optical pulse with a time resolution of a few femtoseconds. By measuring the yields of fragment ions as a function of the delay between the XUV pulse and the probe pulse, a number of transient processes typically lasting 100 femtoseconds or less were observed. These were particularly strong in thymidine which consists of the thymine base attached to a deoxyribose sugar. This dynamics was interpreted as excited states of the cation, formed by the XUV pulse, rapidly decaying via non-adiabatic coupling between electronic states. This provides the first experimental insight into the mechanisms which immediately proceed from the action of ionizing radiation on DNA and provides a basis on which further theoretical and experimental studies can be conducted.

Graphical abstract: Ultrafast dynamics in the DNA building blocks thymidine and thymine initiated by ionizing radiation

Back to tab navigation

Publication details

The article was received on 29 Apr 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7CP02803B
Citation: Phys. Chem. Chem. Phys., 2017,19, 19815-19821
  •   Request permissions

    Ultrafast dynamics in the DNA building blocks thymidine and thymine initiated by ionizing radiation

    E. P. Månsson, S. De Camillis, M. C. Castrovilli, M. Galli, M. Nisoli, F. Calegari and J. B. Greenwood, Phys. Chem. Chem. Phys., 2017, 19, 19815
    DOI: 10.1039/C7CP02803B

Search articles by author

Spotlight

Advertisements