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Issue 24, 2017
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On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

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Abstract

Molecular encapsulation of C60 inside a hydrogen-bond-sealed semi-flexible peptidic capsule is hindered in solution, yet it proceeds effectively after mechanical milling of a solid sample. We show that the molecular mechanism involves the generation of non-covalently disordered forms that are active in guest uptake. We also show that the solvent-free mechanochemical covalent synthesis of capsules directly results in obtaining disordered, active forms.

Graphical abstract: On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

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Publication details

The article was received on 20 Apr 2017, accepted on 26 May 2017 and first published on 09 Jun 2017


Article type: Communication
DOI: 10.1039/C7CP02603J
Citation: Phys. Chem. Chem. Phys., 2017,19, 15676-15680
  • Open access: Creative Commons BY license
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    On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

    M. P. Szymański, H. Jędrzejewska, M. Wierzbicki and A. Szumna, Phys. Chem. Chem. Phys., 2017, 19, 15676
    DOI: 10.1039/C7CP02603J

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