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Issue 45, 2017
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Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous D- and L-tryptophan solutions

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Abstract

The combination of Raman spectroscopy as a sensitive and selective optical measurement technique and multivariate data analysis forms a powerful tool for probing intermolecular interactions between enantiomers. In this study we demonstrate that the optical differentiation of aqueous D- and L-tryptophan solutions is possible using Raman spectroscopy and principal component analysis (PCA). The loadings of the PCA allow identifying these functional groups most relevant for enantiospecific interactions. Through a partial least squares regression (PLSR) a calibration line can be established for the mixing ratio of ternary aqueous D- and L-tryptophan solutions.

Graphical abstract: Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous d- and l-tryptophan solutions

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Publication details

The article was received on 10 Apr 2017, accepted on 18 Oct 2017 and first published on 20 Oct 2017


Article type: Paper
DOI: 10.1039/C7CP02321A
Citation: Phys. Chem. Chem. Phys., 2017,19, 30533-30539
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    Raman microspectroscopy and multivariate data analysis: optical differentiation of aqueous D- and L-tryptophan solutions

    H. Koch, S. Polepil, K. Eisen and S. Will, Phys. Chem. Chem. Phys., 2017, 19, 30533
    DOI: 10.1039/C7CP02321A

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