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Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

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Abstract

We show electric control of unzipping and shearing dehybridization of a DNA duplex anchored to a hydrogel. Tensile force is applied by electrophoresing (25 V cm−1) gold nanoparticles pulling the DNA duplex. The pulled DNA strand is gradually released from the hydrogel. The unzipping release rate is faster than shearing; for example, 3-fold for a 15 base pair duplex, which helps to design electrically driven DNA devices.

Graphical abstract: Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

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Publication details

The article was received on 06 Apr 2017, accepted on 02 May 2017 and first published on 05 May 2017


Article type: Communication
DOI: 10.1039/C7CP02214J
Citation: Phys. Chem. Chem. Phys., 2017, Advance Article
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    Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

    K. Cervantes-Salguero, I. Kawamata, S. M. Nomura and S. Murata, Phys. Chem. Chem. Phys., 2017, Advance Article , DOI: 10.1039/C7CP02214J

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