Effect of nucleoside analogue antimetabolites on the structure of PEO-PPO-PEO micelles investigated by SANS
The effect of three nucleoside analogue antimetabolites (5-Fluorouracil, Floxuridine, and Gemcitabine) on the structure of Pluronic L62 copolymer micelles was investigated using small-angle neutron scattering. These antimetabolites used for cancer chemotherapy have analogous molecular structure but different molecular size and aqueous solubility. It was found that the addition of three antimetabolites slightly reduced the micellar size and aggregation number, and the micellar anisotropy. The added antimetabolites also changed internal molecular distribution of the micelles as measured by scattering length densities, resulting in enhanced hydration of the hydrophobic core region of the micelle. The strength of the effect was found to have correlation with the molecular properties of model drugs, i.e. the larger molecular size and the higher aqueous solubility lead the enhanced hydration of the micellar core.