Jump to main content
Jump to site search

Issue 16, 2017
Previous Article Next Article

Cryptolepine and quindoline: understanding their photophysics

Author affiliations

Abstract

Quindoline (QUIND, indolo[3,2-b]quinoline) and cryptolepine (CRYPT, 5-methyl-10H-indolo[3,2-b]quinoline) together with their corresponding derivatives have been studied for decades due to their important biological activity against diseases like malaria. The biological activity of drugs is routinely investigated using fluorescence based methods. However, recent reports show that the photophysics of CRYPT and its analogues is not yet understood. Herein, the photophysics of CRYPT and QUIND is studied in aqueous solutions at different pH values and in both protic and aprotic solvents of different polarities. CRYPT and QUIND are shown to exist in different prototropic forms depending on pH and solvent polarity. CRYPT is found to be more sensitive to the solvent nature. Both compounds are shown to have two-photon stimulated emission. Their two-photon absorption (TPA) cross-sections were measured in the 710–960 nm range. The TPA cross-section is relatively low but allows for the observation of both compounds in HEK 293 T cells, where CRYPT is found mostly in the nucleus and QUIND accumulates in the cytoplasm.

Graphical abstract: Cryptolepine and quindoline: understanding their photophysics

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jan 2017, accepted on 24 Feb 2017 and first published on 24 Feb 2017


Article type: Paper
DOI: 10.1039/C7CP00455A
Citation: Phys. Chem. Chem. Phys., 2017,19, 10255-10263
  •   Request permissions

    Cryptolepine and quindoline: understanding their photophysics

    I. F. A. Mariz, S. Pinto, J. Lavrado, A. Paulo, J. M. G. Martinho and E. M. S. Maçôas, Phys. Chem. Chem. Phys., 2017, 19, 10255
    DOI: 10.1039/C7CP00455A

Search articles by author

Spotlight

Advertisements