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Thymine cocrystals based on DNA-inspired binding motifs

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Abstract

Nucleic acids have been recognized as an important class of biomolecules for over half a century and are an integral component of many modern pharmaceuticals. Elucidating the associations between DNA nucleobases (thymine, cytosine, adenine and guanine) and other components in both solution and the solid state has wide-ranging applications. Far fewer thymine cocrystals have been reported compared to cocrystals of the other DNA bases. Using schemes inspired by Watson–Crick base pairing motifs, herein we investigate the cocrystallization of thymine and heterocycles with complementary hydrogen bond donors and acceptors. Our coformer screen yielded three new 1 : 1 cocrystals with thymine, only two of which exhibited the expected binding motif. The difficulties encountered in this nucleobase study serve to highlight some of the special challenges associated with cocrystallization of tautomeric components.

Graphical abstract: Thymine cocrystals based on DNA-inspired binding motifs

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Publication details

The article was received on 21 Jul 2017, accepted on 05 Sep 2017 and first published on 13 Sep 2017


Article type: Paper
DOI: 10.1039/C7CE01347G
Citation: CrystEngComm, 2017, Advance Article
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    Thymine cocrystals based on DNA-inspired binding motifs

    E. S. Koch, K. A. McKenna, H. J. Kim, V. G. Young and J. A. Swift, CrystEngComm, 2017, Advance Article , DOI: 10.1039/C7CE01347G

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