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Selective Crystallisation of Carbamazepine Polymorphs on Differing Surface Properties

Abstract

Surface-induced nucleation of carbamazepine (CBZ) in ethanol was investigated with different surface materials; glass, polytetrafluoroethylene (PTFE) and tin. The introduction of foreign surfaces with different areas and surface chemistry into the solution had an impact on the crystal morphology and polymorphic form (Form II or III). With increase in supersaturation, a higher possibility of crystallisation of CBZ metastable Form II was observed, as expected. Increasing the number of inserts resulted in a direct increase in the surface area available for heterogeneous nucleation. The increase in surface area resulted in the greater possibility of obtaining the metastable Form II of CBZ. The stable Form III preferred to nucleate on tin than on glass and PTFE. The results indicate the two different polymorph of CBZ can be selectively crystalliesd out from solution with the aid of a foreign surface. The kinetics mechanism of heterogeneous nucleation of different polymorphs induced by foreign surfaces were discussed. The potential applications will be used to control and design the crystallisation process.

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Publication details

The article was received on 18 Jul 2017, accepted on 13 Sep 2017 and first published on 14 Sep 2017


Article type: Paper
DOI: 10.1039/C7CE01317E
Citation: CrystEngComm, 2017, Accepted Manuscript
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    Selective Crystallisation of Carbamazepine Polymorphs on Differing Surface Properties

    H. Yang, C. L. Song, Y. X. S. Lim, W. Chen and J. Y. Y. Heng, CrystEngComm, 2017, Accepted Manuscript , DOI: 10.1039/C7CE01317E

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