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A hydrostable anionic zinc-organic framework carrier with a bcu topology for drug delivery

Abstract

A hydrostable anionic porous drug carrier MOF with a bcu topology constructed from trinuclear clusters, [(Me2NH2)2Zn3(fdc)4]n•DMA (1) (fdc = 2,5-furandicarboxylate, DMA = dimethylacetamide) was synthesized and structurally characterized. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. 1 exhibits a 3D framework with the rectangular channels of 10.0 × 7.7 and 6.1 × 7.8 Å2 along the b axis, respectively. Desolvated 1 adsorbs around 17.2 wt% of 5-fluorouracil and the cumulative release value of 5-fluorouracil at 72 h was about 93.3% in PBS (pH 7.4) at 37 ºC. The in vivo Zebrafish toxicity tests and in vitro MTT assays of 1 at different concentrations results reveal that 1 is nontoxic.

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Publication details

The article was received on 05 Jul 2017, accepted on 02 Aug 2017 and first published on 02 Aug 2017


Article type: Paper
DOI: 10.1039/C7CE01238A
Citation: CrystEngComm, 2017, Accepted Manuscript
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    A hydrostable anionic zinc-organic framework carrier with a bcu topology for drug delivery

    J. wang, D. Ma, W. Liao, S. Li, M. Huang, H. Liu, Y. Wang, R. Xie and J. xu, CrystEngComm, 2017, Accepted Manuscript , DOI: 10.1039/C7CE01238A

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