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Growth mechanism study of clustered aggregates of dirithromycin crystals in N,N-dimethylformamide solvent

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Abstract

A novel self-aggregated cluster of the pharmaceutical compound dirithromycin was observed through a solvent evaporation-induced method. The initial y-elongated hexagonal crystals experienced repeat attachment and growth process, according to the growth law of critical size λ and adsorption angle θ, to assemble such unique clustered aggregates. These results suggest that the solvent plays a critical role in the crystal growth of aggregated clusters of dirithromycin. The oriented attachment and the interaction between the solvent N,N-dimethylformamide (DMF) and the solute dirithromycin were used to rationalize the observed morphologies of the aggregates.

Graphical abstract: Growth mechanism study of clustered aggregates of dirithromycin crystals in N,N-dimethylformamide solvent

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Publication details

The article was received on 04 Jul 2017, accepted on 18 Aug 2017 and first published on 18 Aug 2017


Article type: Paper
DOI: 10.1039/C7CE01233K
Citation: CrystEngComm, 2017, Advance Article
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    Growth mechanism study of clustered aggregates of dirithromycin crystals in N,N-dimethylformamide solvent

    Y. Wang and Z. Liang, CrystEngComm, 2017, Advance Article , DOI: 10.1039/C7CE01233K

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