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A Ce(IV)-based metal-organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

Abstract

A Ce(IV)-based metal-organic framework (MOF; 1) with UiO-66 (UiO: University of Oslo) framework topology was synthesized solvothermally by employing 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylic acid as a ligand. The MOF was thoroughly characterized by X-ray powder diffraction, infrared spectroscopy, themogravimetric and N2 sorption analyses. The activated material (1') retained its structural integrity in water, acetic acid and 1M HCl solution. Owing to the presence of Ce(IV) ions, 1' was able to oxidize the chromogenic peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) or 2,2′-azinobis(3-ethylbenzothizoline-6-sulfonic acid) (AzBTS) in the absence of an external oxidizing agent. Thus, it showed inherent oxidase-like catalytic properties. Inspired by the excellent oxidase-mimic activity of 1', a protocol was developed for the rapid colorimetric sensing of biothiols in NaAc buffer (0.2 M, pH = 4). The sensing ability of 1' towards cysteine was also demonstrated in human blood plasma. Furthermore, the redox-active Ce(IV) ions enabled 1' to exhibit excellent heterogeneous catalytic performance in aerobic oxidation catalysis of thiol compounds. The material is reusable (both as sensor and catalyst), low-cost and highly stable, which renders it a promising candidate for monitoring of biothiols in immunoassays and medical diagnosis as well as for industrial oxidation catalysis.

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Publication details

The article was received on 05 Jun 2017, accepted on 05 Sep 2017 and first published on 06 Sep 2017


Article type: Paper
DOI: 10.1039/C7CE01053B
Citation: CrystEngComm, 2017, Accepted Manuscript
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    A Ce(IV)-based metal-organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

    R. Dalapati, S. Balasubramanian, M. K. Ghosalya, D. Amarajothi and S. Biswas, CrystEngComm, 2017, Accepted Manuscript , DOI: 10.1039/C7CE01053B

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