Jump to main content
Jump to site search

Issue 39, 2017
Previous Article Next Article

A cerium-based metal–organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

Author affiliations

Abstract

A cerium-based metal–organic framework (MOF; 1) with a UiO-66 (UiO: University of Oslo) framework topology was synthesized solvothermally by employing 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylic acid as a ligand. The MOF was thoroughly characterized by X-ray photoelectron spectroscopy (XPS), X-ray powder diffraction, infrared spectroscopy, and thermogravimetric and N2 sorption analyses. The activated material (1′) retained its structural integrity in water, acetic acid and 1 M HCl solution. XPS investigation reveals the presence of both Ce(III) and Ce(IV) ions in 1. Owing to the presence of mixed-valence cerium ions, 1′ was able to oxidize the chromogenic peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) or 2,2′-azinobis(3-ethylbenzothizoline-6-sulfonic acid) (AzBTS) in the absence of an external oxidizing agent. Thus, it showed inherent oxidase-like catalytic properties. Inspired by the excellent oxidase-mimicking activity of 1′, a protocol was developed for the rapid colorimetric sensing of biothiols in NaAc buffer (0.2 M, pH = 4). The sensing ability of 1′ towards cysteine was also demonstrated in human blood plasma. Furthermore, the redox-active cerium ions enabled 1′ to exhibit excellent heterogeneous catalytic performance in aerobic oxidation catalysis of thiol compounds. The material is reusable (both as a sensor and as a catalyst), low-cost and highly stable, which renders it a promising candidate for the monitoring of biothiols in immunoassays and medical diagnosis as well as for industrial oxidation catalysis.

Graphical abstract: A cerium-based metal–organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jun 2017, accepted on 05 Sep 2017 and first published on 06 Sep 2017


Article type: Paper
DOI: 10.1039/C7CE01053B
Citation: CrystEngComm, 2017,19, 5915-5925
  •   Request permissions

    A cerium-based metal–organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols

    R. Dalapati, B. Sakthivel, M. K. Ghosalya, A. Dhakshinamoorthy and S. Biswas, CrystEngComm, 2017, 19, 5915
    DOI: 10.1039/C7CE01053B

Search articles by author

Spotlight

Advertisements