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Issue 27, 2017
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Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

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Abstract

We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid. The dehydration of cocrystals of macro-dimensions results in destruction of crystal morphology; however, crystal morphology is retained when the cocrystal is reduced to nanometer-dimensions, despite a lack of pores to accommodate loss of water.

Graphical abstract: Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

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Publication details

The article was received on 02 May 2017, accepted on 15 Jun 2017 and first published on 16 Jun 2017


Article type: Communication
DOI: 10.1039/C7CE00826K
Citation: CrystEngComm, 2017,19, 3723-3726
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    Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

    K. E. Peterson, R. F. Henry, G. G. Z. Zhang and L. R. MacGillivray, CrystEngComm, 2017, 19, 3723
    DOI: 10.1039/C7CE00826K

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