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Relating induction time and metastable zone width

Abstract

A relation between induction time and metastable zone width in cooling crystallization has been developed based on the correlation between temperature and supersaturation with induction time in Classical Nucleation Theory. By this relation the nucleation times in linear cooling experiments and the induction times at constant temperature can be estimated from each other, i.e. estimating metastable zone widths from experimental induction times or interfacial energy and the pre-exponential factor from metastable zone widths. 120 induction times and 192 metastable zone widths of ascorbic acid in water have been determined, together with several systems reported in the literature, have been investigated to compare the estimated values of metastable zone width / induction time with experimental values, respectively. The estimated metastable zone widths are fairly consistent with the experimental values. The differences between experimental literature values of metastable zone widths with the estimated values using the literature induction times range from 0.1 K to 10 K with an average of 2.5 K. For two systems (paracetamol in ethanol and salicylic acid in ethyl acetate) estimated and experimental results are of very good consistency with the average uncertainty only about 5%. More accurate extrapolations of the induction times from metastable zone widths have been investigated. The potential utilities of this approach in crystallization research and process understanding are discussed.

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Publication details

The article was received on 24 Apr 2017, accepted on 13 Jun 2017 and first published on 13 Jun 2017


Article type: Paper
DOI: 10.1039/C7CE00770A
Citation: CrystEngComm, 2017, Accepted Manuscript
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    Relating induction time and metastable zone width

    H. Yang and A. J. Florence, CrystEngComm, 2017, Accepted Manuscript , DOI: 10.1039/C7CE00770A

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