Jump to main content
Jump to site search

Ionic Cocrystals of Molecular Saccharin


Saccharin is a cyclic sulfimide whose sodium salt, commercially available under the trade name "Sweet’N Low" is one of the most commonly used artificial low-calorie sweeteners, and is also the main sugar substitute in the diabetics’ diet. Being an acid (pKa = 1.6), it is readily deprotonated in solution and affords solid ionic salts or coordination compounds with transition metals where its conjugate base (saccharinate ion) displays a wealth of coordination modes. Here we report the first two examples of ionic cocrystals of molecular saccharin where saccharin exists as a neutral species and an ion in the same crystal. With rubidium and cesium cations, saccharin forms isomorphous solid hemihydrate salts. When saccharin is supplied in excess to the reaction mixture, neutral saccharin molecules are stoichiometrically incorporated in both crystals and stable isomorphous ionic cocrystals are obtained. The formation of ionic cocrystals is unprecedented, and adds a new aspect to the rich crystal chemistry of the artificial sweetener.

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Apr 2017, accepted on 15 Jun 2017 and first published on 16 Jun 2017

Article type: Paper
DOI: 10.1039/C7CE00627F
Citation: CrystEngComm, 2017, Accepted Manuscript
  •   Request permissions

    Ionic Cocrystals of Molecular Saccharin

    D. P. Karothu, I. Jahovic, G. Jovanovski , B. Kaitner and P. Naumov, CrystEngComm, 2017, Accepted Manuscript , DOI: 10.1039/C7CE00627F

Search articles by author