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Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

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Abstract

Cocrystals of the FDA-approved boron-containing API Tavaborole (AN2690) were obtained through solvent evaporation with coformers functionalized with 4-pyridyl groups. The components form three- and four-component supramolecular assemblies sustained by a combination of (B)OH⋯Npyr hydrogen bonds and C–H⋯F interactions, as demonstrated by single-crystal X-ray diffraction analysis. Three cocrystals are isostructural.

Graphical abstract: Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

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Publication details

The article was received on 14 Feb 2017, accepted on 03 Apr 2017 and first published on 03 Apr 2017


Article type: Paper
DOI: 10.1039/C7CE00314E
Citation: CrystEngComm, 2017, Advance Article
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    Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

    G. Campillo-Alvarado, C. A. Staudt, M. J. Bak and L. R. MacGillivray, CrystEngComm, 2017, Advance Article , DOI: 10.1039/C7CE00314E

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