Jump to main content
Jump to site search


An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp3)–H functionalization

Author affiliations

Abstract

A Mn-promoted intermolecular oxidative radical heteroannulation of N-(2-cyanoaryl)-acrylamides and tertiary silanes has been described, which provides an efficient route to produce silicon/nitrogen heterocycles, sila-analogues of the known carbon-based structural motifs prevalent in bioactive natural products, pharmaceuticals and materials. The reaction enables Si-incorporation by controlling accurately several chemical bond cleavage and formation processes. Moreover, this reaction represents a new one-step construction of 1,3-azasiline-fused quinolinones that was achieved via silyl C(sp3)–H functionalization using an oxidative radical strategy.

Graphical abstract: An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp3)–H functionalization

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Nov 2017, accepted on 18 Dec 2017 and first published on 19 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08996A
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp3)–H functionalization

    L. Wu, Y. Yang, R. Song, J. Yu, J. Li and D. He, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08996A

Search articles by author

Spotlight

Advertisements