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Diverse Ring Opening of Thietanes and Other Cyclic Sulfides: an Electrophilic Aryne Activation Approach

Abstract

Organosulfides are a common class of structure units in bioactive molecules and functional materials, motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of saturated one or two heteroatoms containing sulfur heterocycles. This three-component transformation proceeds under mild conditions and displays exceptional generality of nucleophiles (C, O, S, N, and F centered nucleophiles), giving the structurally diverse thioethers in good yields.

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Publication details

The article was received on 09 Nov 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08553B
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Diverse Ring Opening of Thietanes and Other Cyclic Sulfides: an Electrophilic Aryne Activation Approach

    T. Zheng, J. Tan, R. Fan, S. Su, B. Liu, C. Tan and K. Xu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC08553B

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