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Issue 100, 2017
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A small molecule for theraNOstic targeting of cancer cells

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Abstract

Thera/NO – a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO.

Graphical abstract: A small molecule for theraNOstic targeting of cancer cells

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Publication details

The article was received on 06 Nov 2017, accepted on 20 Nov 2017 and first published on 20 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08526E
Citation: Chem. Commun., 2017,53, 13352-13355
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    A small molecule for theraNOstic targeting of cancer cells

    G. Ravikumar, M. Bagheri, D. K. Saini and H. Chakrapani, Chem. Commun., 2017, 53, 13352
    DOI: 10.1039/C7CC08526E

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