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Multifunctional Chiral Phosphine-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclopentenones: Asymmetric Synthesis of 4-oxo-Hexahydropentalenes

Abstract

A multifunctional chiral phosphine-catalyzed enantioselective [3+2] annulation of Morita-Baylis-Hillman carbonates with cyclopentenones provides a direct approach to functional 4-oxo-1,3a,4,5,6,6a-hexahydropentalene compounds. Moderate to good yields and excellent enantioselectivities (> 90% ee) were obtained for a series of substrates under mild reaction condition.

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Publication details

The article was received on 31 Oct 2017, accepted on 05 Dec 2017 and first published on 05 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08380G
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Multifunctional Chiral Phosphine-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclopentenones: Asymmetric Synthesis of 4-oxo-Hexahydropentalenes

    H. Guo, C. Wang, Z. Gao, L. Zhou, Q. Wang, Y. Wu, C. Yuan, J. Liao and Y. Xiao, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC08380G

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