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Issue 98, 2017
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Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles

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Abstract

A transition metal free, straightforward synthetic method for the preparation of substituted imidazoles is reported herein. Base promoted, deaminative coupling of benzylamines with nitriles results in the one-step synthesis of 2,4,5-trisubstituted imidazoles with liberation of ammonia. This protocol provides a practical strategy for the synthesis of valuable imidazole derivatives from readily available starting materials.

Graphical abstract: Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles

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Publication details

The article was received on 28 Oct 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08322J
Citation: Chem. Commun., 2017,53, 13133-13136
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    Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles

    U. K. Das, L. J. W. Shimon and D. Milstein, Chem. Commun., 2017, 53, 13133
    DOI: 10.1039/C7CC08322J

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