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Imidazoles Synthesis by Transition Metal Free, Base‐Mediated Deaminative Coupling of Benzylamines and Nitriles

Abstract

A transition metal free, straightforward synthetic method for the preparation of substituted imidazoles is reported herein. Base promoted, deaminative coupling of benzylamines with nitriles results in the one-step synthesis of 2,4,5-trisubstituted imidazole with liberation of ammonia. This protocol provides a practical strategy for synthesis of valuable imidazole derivatives from readily available starting materials.

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Publication details

The article was received on 28 Oct 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08322J
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Imidazoles Synthesis by Transition Metal Free, Base‐Mediated Deaminative Coupling of Benzylamines and Nitriles

    U. K. Das, L. Shimon and D. Milstein, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC08322J

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