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Issue 92, 2017
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Solvent-free iodine-promoted synthesis of 3,2′-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions

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Abstract

A novel solvent-free iodine-promoted cyclization of alkylidene oxindoles with enamino esters via C–C/C–N bond formation has been demonstrated under ball-milling conditions. This protocol provides efficient and green access to a variety of 3,2′-pyrrolinyl spirooxindoles with remarkable functional group tolerance, good yields and excellent diastereoselectivities.

Graphical abstract: Solvent-free iodine-promoted synthesis of 3,2′-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions

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Publication details

The article was received on 27 Oct 2017, accepted on 30 Oct 2017 and first published on 03 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08306H
Citation: Chem. Commun., 2017,53, 12477-12480
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    Solvent-free iodine-promoted synthesis of 3,2′-pyrrolinyl spirooxindoles from alkylidene oxindoles and enamino esters under ball-milling conditions

    H. Xu, H. Liu, H. Lin and G. Wang, Chem. Commun., 2017, 53, 12477
    DOI: 10.1039/C7CC08306H

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