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Half-sandwich ruthenium(II) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

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Abstract

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

Graphical abstract: Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

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Publication details

The article was received on 26 Oct 2017, accepted on 06 Nov 2017 and first published on 07 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08270C
Citation: Chem. Commun., 2017, Advance Article
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    Half-sandwich ruthenium(II) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells

    M. Tian, J. Li, S. Zhang, L. Guo, X. He, D. Kong, H. Zhang and Z. Liu, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC08270C

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