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Issue 97, 2017
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Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

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Abstract

The (5 + 1) annulation of ynone/cinnamates and related substrates with protected primary amines gives rise to isoquinolones, pyrrolidinones and pyrrolopiperazines in good to excellent yields under phosphine catalysis. The reaction is viable with chiral phosphines, although the selectivity is poor.

Graphical abstract: Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

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Publication details

The article was received on 26 Oct 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08252E
Citation: Chem. Commun., 2017,53, 13071-13074
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    Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

    J. Ametovski, U. Dutta, L. Burchill, D. Maiti, D. W. Lupton and J. F. Hooper, Chem. Commun., 2017, 53, 13071
    DOI: 10.1039/C7CC08252E

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