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Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

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Abstract

This work describes the synthesis of azidonaphthalimide carboxylic acids which act as fluorescent templates with a built-in photoreactive group and a linker thus simplifying the design of protein labeling agents. These were separately connected to selectivity hands like a sulfonamide and ampicillin for successful labeling/detection of HCAII and PBPs, respectively.

Graphical abstract: Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

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Publication details

The article was received on 24 Oct 2017, accepted on 06 Nov 2017 and first published on 06 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08209F
Citation: Chem. Commun., 2017, Advance Article
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    Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

    M. Singha, S. Roy, S. D. Pandey, S. S. Bag, P. Bhattacharya, M. Das, A. S. Ghosh, D. Ray and A. Basak, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC08209F

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