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Issue 92, 2017
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Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

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Abstract

We developed a dual-target theranostic F671, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F671 undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.

Graphical abstract: Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

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Publication details

The article was received on 23 Oct 2017, accepted on 30 Oct 2017 and first published on 30 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC08162F
Citation: Chem. Commun., 2017,53, 12406-12409
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    Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition

    Z. Li, J. Ding, C. Chen, J. Chang, B. Huang, Z. Geng and Z. Wang, Chem. Commun., 2017, 53, 12406
    DOI: 10.1039/C7CC08162F

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