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Formal total synthesis of the akuammiline alkaloid (+)-strictamine

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Abstract

An asymmetric formal total synthesis of the akuammiline alkaloid (+)-strictamine is reported. The key features of the synthesis include a Friedel–Crafts cyclization to form the D-ring and the critical C7 all-carbon quaternary carbon centre, as well as an aza-1,6-conjugate addition to assemble the 2-azabicyclo[3.3.1]nonane system.

Graphical abstract: Formal total synthesis of the akuammiline alkaloid (+)-strictamine

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Publication details

The article was received on 22 Oct 2017, accepted on 01 Nov 2017 and first published on 02 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08153G
Citation: Chem. Commun., 2017, Advance Article
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    Formal total synthesis of the akuammiline alkaloid (+)-strictamine

    T. Xiao, Z. Chen, L. Deng, D. Zhang, X. Liu, H. Song and Y. Qin, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC08153G

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