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Iron-catalyzed peroxidation–carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)–H functionalization

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Abstract

A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation.

Graphical abstract: Iron-catalyzed peroxidation–carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)–H functionalization

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Publication details

The article was received on 19 Oct 2017, accepted on 01 Nov 2017 and first published on 01 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08074C
Citation: Chem. Commun., 2017, Advance Article
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    Iron-catalyzed peroxidation–carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)–H functionalization

    J. Cheng, L. Shen, L. Wu, X. Hu and T. Loh, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC08074C

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