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Issue 99, 2017
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5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

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Abstract

DNA templates containing 5-hydroxymethyluracil or 5-hydroxymethylcytosine were used in an in vitro transcription assay with RNA polymerase from Escherichia coli. A strong enhancement of transcription was observed from DNA containing the Pveg promoter whereas a decrease was observed from DNA containing the rrnB P1 promoter, suggesting that they may act as epigenetic marks.

Graphical abstract: 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

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Publication details

The article was received on 18 Oct 2017, accepted on 21 Nov 2017 and first published on 22 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08053K
Citation: Chem. Commun., 2017,53, 13253-13255
  • Open access: Creative Commons BY license
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    5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase

    M. Janoušková, Z. Vaníková, F. Nici, S. Boháčová, D. Vítovská, H. Šanderová, M. Hocek and L. Krásný, Chem. Commun., 2017, 53, 13253
    DOI: 10.1039/C7CC08053K

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