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NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3’-spirocyclic oxindoles via C−F bond cleavage protocol

Abstract

A chiral NHC-catalyzed [4+2] cycloaddition of γ-fluoroenals is developed. This catalytically generated nucleophlic γ-carbon via C−F bond cleavage undergoes highly enantioselective cycloaddition (up to >99% ee) to isatins and provides 3’-spirocyclic oxindoles in good to excellent yields (up to 91%).

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Publication details

The article was received on 18 Oct 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08048D
Citation: Chem. Commun., 2017, Accepted Manuscript
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    NHC-catalyzed [4+2] cycloaddition reactions for the synthesis of 3’-spirocyclic oxindoles via C−F bond cleavage protocol

    J. Yan, K. Shi, C. Zhao, L. Ding, S. Jiang, L. Yang and G. Zhong, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC08048D

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