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Issue 100, 2017
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Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

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Abstract

A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.

Graphical abstract: Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

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Publication details

The article was received on 18 Oct 2017, accepted on 20 Nov 2017 and first published on 21 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08039E
Citation: Chem. Commun., 2017,53, 13359-13362
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    Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

    C. Mou, J. Wu, Z. Huang, J. Sun, Z. Jin and Y. R. Chi, Chem. Commun., 2017, 53, 13359
    DOI: 10.1039/C7CC08039E

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