Issue 99, 2017

Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

Abstract

A new pair of enantiomeric two-armed lanthanide-binding tags have been developed for paramagnetic NMR studies of proteins. The tags produce large and significantly different paramagnetic effects to one another when bound to the same tagging site. Additionally, they are less sensitive to sample pH than our previous two-armed tag designs.

Graphical abstract: Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
15 Oct 2017
Accepted
15 Nov 2017
First published
15 Nov 2017

Chem. Commun., 2017,53, 13205-13208

Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

M. D. Lee, M. L. Dennis, B. Graham and J. D. Swarbrick, Chem. Commun., 2017, 53, 13205 DOI: 10.1039/C7CC07961C

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