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Issue 99, 2017
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Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

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Abstract

A new pair of enantiomeric two-armed lanthanide-binding tags have been developed for paramagnetic NMR studies of proteins. The tags produce large and significantly different paramagnetic effects to one another when bound to the same tagging site. Additionally, they are less sensitive to sample pH than our previous two-armed tag designs.

Graphical abstract: Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

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Publication details

The article was received on 15 Oct 2017, accepted on 15 Nov 2017 and first published on 15 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07961C
Citation: Chem. Commun., 2017,53, 13205-13208
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    Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

    M. D. Lee, M. L. Dennis, B. Graham and J. D. Swarbrick, Chem. Commun., 2017, 53, 13205
    DOI: 10.1039/C7CC07961C

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