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Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion

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Abstract

Griseofulvin (GSF) is a classic antifungal drug that has been in clinical use for over 50 years, but its polymorphism was recognized only recently via melt crystallization. Here we report the structure of a single crystal of GSF form II which was unusually harvested from the supercooled melt. GSF form II exhibits an anomalously large thermal expansion coefficient.

Graphical abstract: Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion

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Publication details

The article was received on 06 Oct 2017, accepted on 04 Dec 2017 and first published on 04 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC07744K
Citation: Chem. Commun., 2018, Advance Article
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    Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion

    Y. Su, J. Xu, Q. Shi, L. Yu and T. Cai, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC07744K

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