Jump to main content
Jump to site search


Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

Author affiliations

Abstract

High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.

Graphical abstract: Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Oct 2017, accepted on 07 Nov 2017 and first published on 07 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07732G
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

    L. A. Mike, A. Tripathi, C. M. Blankenship, A. Saluk, P. J. Schultz, G. Tamayo-Castillo, D. H. Sherman and H. L. T. Mobley, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07732G

Search articles by author

Spotlight

Advertisements