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Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

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Abstract

Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of β-glucosidases and β-galactosidases.

Graphical abstract: Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

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Publication details

The article was received on 05 Oct 2017, accepted on 03 Nov 2017 and first published on 03 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07730K
Citation: Chem. Commun., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

    S. P. Schröder, J. W. van de Sande, W. W. Kallemeijn, C. Kuo, M. Artola, E. J. van Rooden, J. Jiang, T. J. M. Beenakker, B. I. Florea, W. A. Offen, G. J. Davies, A. J. Minnaard, J. M. F. G. Aerts, J. D. C. Codée, G. A. van der Marel and H. S. Overkleeft, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07730K

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