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Issue 5, 2018
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Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

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Abstract

Here we show that the base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 is a powerful methodology to synthesize quinoline-2-thiones. This thio-lactamization uses inexpensive and versatile 2-(1-arylvinyl)anilines, which are easily available from the reaction of amines and alkynes. Compared to the known strategy in the literature, this method features the advantages like a short synthesis step and easily available starting materials.

Graphical abstract: Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

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Publication details

The article was received on 30 Sep 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC07633A
Citation: Chem. Commun., 2018,54, 499-502
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    Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

    T. Wang, X. Liu, C. Huo, X. Wang and Z. Quan, Chem. Commun., 2018, 54, 499
    DOI: 10.1039/C7CC07633A

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