Issue 5, 2018

Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

Abstract

Here we show that the base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 is a powerful methodology to synthesize quinoline-2-thiones. This thio-lactamization uses inexpensive and versatile 2-(1-arylvinyl)anilines, which are easily available from the reaction of amines and alkynes. Compared to the known strategy in the literature, this method features the advantages like a short synthesis step and easily available starting materials.

Graphical abstract: Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

Supplementary files

Article information

Article type
Communication
Submitted
30 Sep 2017
Accepted
07 Dec 2017
First published
07 Dec 2017

Chem. Commun., 2018,54, 499-502

Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones

T. Wang, X. Liu, C. Huo, X. Wang and Z. Quan, Chem. Commun., 2018, 54, 499 DOI: 10.1039/C7CC07633A

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