Jump to main content
Jump to site search


A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity

Author affiliations

Abstract

29-40 residues with tryptophan in place of the lone methionine residue and three arginine residues added to its C-terminus exhibited augmented antibacterial activities and protected mice against a lethal dose of LPS. The results show the conversion of a Aβ29-40 segment into a cell-selective antimicrobial/anti-endotoxin peptide with nanostructure and cation–π interaction.

Graphical abstract: A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Sep 2017, accepted on 09 Nov 2017 and first published on 13 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07547B
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity

    M. K. Harioudh, R. Sahai, K. Mitra and J. K. Ghosh, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07547B

Search articles by author

Spotlight

Advertisements