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A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts nanostructure and shows in vivo anti-endotoxin activity

Abstract

Aβ29-40 residues with tryptophan in place of the lone methionine residue and three arginine residues added to its C-terminus exhibited augmented antibacterial activity and protected mice against a lethal dose of LPS. The results show the conversion of Aβ29-40 segment into a cell-selective antimicrobial/anti-endotoxin peptide having nanostructure and cation-π interaction.

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Publication details

The article was received on 27 Sep 2017, accepted on 09 Nov 2017 and first published on 13 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07547B
Citation: Chem. Commun., 2017, Accepted Manuscript
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    A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts nanostructure and shows in vivo anti-endotoxin activity

    M. K. Harioudh, R. Sahai, K. Mitra and J. K. Ghosh, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC07547B

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