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Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5

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Abstract

Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b5. These results highlight the importance of lipid membrane for the function of P450.

Graphical abstract: Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5

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Publication details

The article was received on 26 Sep 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07520K
Citation: Chem. Commun., 2017, Advance Article
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    Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5

    T. Ravula, C. Barnaba, M. Mahajan, G. M. Anantharamaiah, S. Im, L. Waskell and A. Ramamoorthy, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07520K

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