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Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals

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Abstract

We report a novel proton-detected MAS solid-state NMR strategy based on 15N–15N proton assisted recoupling to detect the inter-nucleotide NH⋯N hydrogen bonds within the Watson–Crick base pairs of micro-crystallized dimeric RNA and to confirm the kissing-loop structure. This would contribute to advances in the structural determination of RNA using solid-state NMR.

Graphical abstract: Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals

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Publication details

The article was received on 25 Sep 2017, accepted on 26 Oct 2017 and first published on 26 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07483B
Citation: Chem. Commun., 2017, Advance Article
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    Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals

    Y. Yang, S. Xiang, X. Liu, X. Pei, P. Wu, Q. Gong, N. Li, M. Baldus and S. Wang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07483B

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