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Issue 92, 2017
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Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

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Abstract

We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells.

Graphical abstract: Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

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Publication details

The article was received on 25 Sep 2017, accepted on 27 Oct 2017 and first published on 27 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07465D
Citation: Chem. Commun., 2017,53, 12438-12441
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    Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

    Q. Meng, J. Meng, W. Ran, J. Su, Y. Yang, P. Zhang and Y. Li, Chem. Commun., 2017, 53, 12438
    DOI: 10.1039/C7CC07465D

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