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Issue 84, 2017
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Effect of buffer at nanoscale molecular recognition interfaces – electrostatic binding of biological polyanions

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Abstract

We investigate the impact of an over-looked component on molecular recognition in water–buffer. The binding of a cationic dye to biological polyanion heparin is shown by isothermal calorimetry to depend on buffer (Tris–HCl > HEPES > PBS). The heparin binding of self-assembled multivalent (SAMul) cationic micelles is even more buffer dependent. Multivalent electrostatic molecular recognition is buffer dependent as a result of competitive interactions between the cationic binding interface and anions present in the buffer.

Graphical abstract: Effect of buffer at nanoscale molecular recognition interfaces – electrostatic binding of biological polyanions

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Publication details

The article was received on 22 Sep 2017, accepted on 05 Oct 2017 and first published on 09 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07413A
Citation: Chem. Commun., 2017,53, 11580-11583
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    Effect of buffer at nanoscale molecular recognition interfaces – electrostatic binding of biological polyanions

    A. C. Rodrigo, E. Laurini, V. M. P. Vieira, S. Pricl and D. K. Smith, Chem. Commun., 2017, 53, 11580
    DOI: 10.1039/C7CC07413A

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