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DNA-Crowded Enzyme Complexes with Enhanced Activities and Stabilities

Abstract

We present a robust and simple method to prepare DNA-crowded enzyme nanoparticles by directly assembling long DNA duplexes on the enzyme surface. DNA-crowded enzyme nanoparticles show boosted substrate turnover numbers, and increased stabilities against various storage conditions. They could be potentially scaled up for applications in biomaterials and biotechnology.

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Publication details

The article was received on 21 Sep 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07361E
Citation: Chem. Commun., 2017, Accepted Manuscript
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    DNA-Crowded Enzyme Complexes with Enhanced Activities and Stabilities

    J. Collins, T. Zhang, S. W. Oh, R. Maloney and J. Fu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC07361E

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