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Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential

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Abstract

We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.

Graphical abstract: Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential

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Publication details

The article was received on 17 Sep 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07285F
Citation: Chem. Commun., 2017, Advance Article
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    Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential

    P. Teng, A. Nimmagadda, M. Su, Y. Hong, N. Shen, C. Li, L. Tsai, J. Cao, Q. Li and J. Cai, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07285F

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