Jump to main content
Jump to site search


N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals

Author affiliations

Abstract

An efficient N-heterocyclic carbene (NHC) catalyzed sulfa-Michael addition (SMA) between enals and thiols has been developed. Under the catalysis of 10 mol% stable free carbene IPr and with 20 mol% hexafluoroisopropanol (HFIP) as an additive, enals react with a variety of thiols to afford the SMA adducts in 54–98% yields. In this process, the free carbene preferentially interacts with thiols through hydrogen-bonding and no NHC-catalyzed extended Umpolung transformations were observed.

Graphical abstract: N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2017, accepted on 13 Nov 2017 and first published on 13 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07269D
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals

    Z. Cong, Y. Li, G. Du, C. Gu, B. Dai and L. He, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07269D

Search articles by author

Spotlight

Advertisements