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Organocatalyst-assisted Ar–18F bond formation: a universal procedure for direct aromatic radiofluorination

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Abstract

A metal free, phosphane-catalysed protocol for C–F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. With operational ease and mild conditions, the method promises a high potential for radiolabelling of biomolecules.

Graphical abstract: Organocatalyst-assisted Ar–18F bond formation: a universal procedure for direct aromatic radiofluorination

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Publication details

The article was received on 14 Sep 2017, accepted on 23 Oct 2017 and first published on 23 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07211B
Citation: Chem. Commun., 2017, Advance Article
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    Organocatalyst-assisted Ar–18F bond formation: a universal procedure for direct aromatic radiofluorination

    J. E. Jakobsson, G. Grønnevik and P. J. Riss, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07211B

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